Morpholino oligos forum: topic
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Vivo-Morpholino publications
Jon Moulton
Monday, 23 June 2008 16:59 UTC
So far, there has been a presentation and now a paper reporting results with Vivo-Morpholinos in mice.
The paper reports delivery in transgenic mice with an EGFP splice-reporter system:
Li YF, Morcos PA. Design and Synthesis of Dendritic Molecular Transporter that Achieves Efficient in Vivo Delivery of Morpholino Antisense Oligo. Bioconjug Chem. 2008 Jun 20. [Epub ahead of print]
The presentation described the use of Vivo-Morpholinos in mdx mice, a mouse model of Duchenne muscular dystrophy:
Wu B, Li Y, Morcos PA, Doran TJ, Lu P, Lu QL. Restoration of Dystrophin Expression in Skeletal and Cardiac Muscle by Systemic Delivery of MorpholinoE23-Vivo Porter Oligonucleotide. 2008. Abstract 433, Annual Meeting of American Society of Gene Therapy, Boston, MA USA.
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