Eberhart JK, He X, Swartz ME, Yan YL, Song H, Boling TC, Kunerth AK, Walker MB, Kimmel CB, Postlethwait JH. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet. 2008 Feb 10; [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/18264099

Appropriate expression of an miRNA, dre-mir-140, is required for proper formation of the palate in zebrafish. Injecting mir-140 duplex RNA causes cleft palate, while inhibiting mir-140 causes migrating neural crest cells (palatal precursors) to stop at the optic stalk and fail to contribute to palate formation. In zebrafish, mir-140 interacts with platelet-derived growth factor receptor a, inhibiting pdgfra translation.