JOURNAL CLUB: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
Maxine Clarke
Wednesday, 02 April 2008 08:27 UTC
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
by J R Vane
Nature New Biology 231, 232-235; 1971.
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
This paper was nominated by Martin Fenner. It is not yet available online, but is in the process of being digitized, and along with the rest of Nature New Biology and Nature Physical Sciences, should be online in the next few months. You can download a PDF of the whole paper at this Nautilus post .
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Replies
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What I like:
- The title is very clear.
- The language used in the paper is easy to follow.
- The format of the paper is different from what we are used today. The subheadings are really helpful to structure the paper.
It is probably just a cheap trick to post papers that later won their authors a Nobel Prize. But I think that very clear, unambigious results make it much easier to write the paper in an easy to follow language.
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I like the one-sentence abstract (reproduced in my post above). Currently, the editors write a one or two-sentence summary of each Nature paper for the table of contents email-alert, and this is sometimes quite hard to summarise the message so succinctly in a way that is clear to all readers. It is fascinating that we were quite happily achieving this feat back in 1971, on this evidence!
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