Genetic Map Distances

Lorna Houlihan

Friday, 20 Jul 2007 13:39 UTC

Hello,
I would like to know how I can convert Marshfield map positions to DeCode map positions, please? My data is in DeCode postitions and I would like to add in data which I have Marshfield co-ordinates. There are no corresponding DeCode postion information for these markers on the UCSC genome browser.
Hopefully someone can point me in the right direction, please?
Thanks,
Lorna

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    • I found such data on the UCSC mysql server (the data is here , but you’ll need to known SQL or ask someone).

      Hope it helps.

      Pierre

      mysql—user=genome—host=genome-mysql.cse.ucsc.edu -A -Dhg18

      mysql> select name,marshfieldChrom,marshfieldPos,decodeChrom,decodePos from stsMap where marshfieldPos>0 or decodePos>0 limit 10\G

      +++++++++++++ 1 row
      name: AFM280WE5
      marshfieldChrom: chr1
      marshfieldPos: 4.22
      decodeChrom: chr1
      decodePos: 4
      +++++++++++++ 2 row
      name: AFM344WE9
      marshfieldChrom: chr1
      marshfieldPos: 8.85
      decodeChrom: chr1
      decodePos: 6.43
      +++++++++++++ 3 row
      name: AFM123XC3
      marshfieldChrom: chr1
      marshfieldPos: 10.78
      decodeChrom: chr1
      decodePos: 6.43
      +++++++++++++ 4 row
      name: AFMA203YC1
      marshfieldChrom: chr1
      marshfieldPos: 10.78
      decodeChrom: chr1
      decodePos: 7.09
      +++++++++++++ 5 row
      name: GATA68D01
      marshfieldChrom: chr1
      marshfieldPos: 10.78
      decodeChrom: chr1
      decodePos: 8.06
      +++++++++++++ 6 row
      name: AFMB355ZH5
      marshfieldChrom: chr1
      marshfieldPos: 11.87
      decodeChrom: 0
      decodePos: 0
      +++++++++++++ 7 row
      name: AFMA131YA5
      marshfieldChrom: chr1
      marshfieldPos: 11.87
      decodeChrom: chr1
      decodePos: 10.11
      +++++++++++++ 8 row
      name: AFMA052WG1
      marshfieldChrom: chr1
      marshfieldPos: 14.04
      decodeChrom: chr1
      decodePos: 11.37
      +++++++++++++ 9 row
      name: AFM254WB9
      marshfieldChrom: chr1
      marshfieldPos: 14.59
      decodeChrom: 0
      decodePos: 0
      +++++++++++++ 10 row
      name: AFMB039ZG9
      marshfieldChrom: chr1
      marshfieldPos: 14.04
      decodeChrom: chr1
      decodePos: 12
      10 rows in set (0,31 sec)

    • BTW,
      you can also download this table from http://hgdownload.cse.ucsc.edu/goldenPath/hg18/database/stsMap.txt.gz

      Pierre

    • Thank you. However, it looks like some of my microsatellite markers do not have any DeCODE co-ordinates. Do you know if there is a way to extrapolate Marshfield co-ordinates to DeCODE co-ordinates?
      Many thanks,
      Lorna

    • If you have flanking markers which are on the DeCode Map, you could use those to translate the DeCode map onto the Marshfield map. It won’t be very accurate doing it this way, but I guess it’s better than nothing.

      So if you data looks like the following:

      Marker DeCode Map Marshfield Map
      Marker1 5 7
      Marker2 5.5 7.4
      Marker3 7.9
      Marker4 6 8.3

      Calculate the Decode units per Marshfield unit for each marker and then use a mean of that value multiplied by the Marshfield position will give you an approximate location for your marker. Does that make sense?
      Cheers,

      Claire

    • Thanks Claire. It does make sense. Actually, I ended up using a program called Cartographer and for in-house markers, I used linear interpolation as done by DeCODE to estimate the DeCODE cM genetic distance.
      Thanks for your help, Lorna

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