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What are your projects/interests in gene mapping?

Barbara Kremeyer

Saturday, 30 Jun 2007 09:18 UTC

Hi everyone,

I thought that, in order to get this discussion forum going, it would be interesting to learn a bit about what we are all doing and what are our special interests in the field of gene mapping. So I am going to start!
I am doing my PhD on bipolar disorder in a population isolate from Antioquia (Colombia). We are working on extended pedigrees as well as trios. My other interest is in schizophrenia, so really I would like to learn more about complex trait mapping, including all possible tools and methods, like QTL mapping etc. I am also interested in learning about how to map several genes at a time, since this seems to be the most realistic approach in terms of how those traits really behave. As for methods, this is something I know really little about, it would be interesting to discuss that here.
…now it’s your turn! :-)

  • Replies

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    • Hi,
      Currently I am working in Immunology (T-cell biology), but I was always fascinated about the QTL mapping and Quantitative Genetics. I worked on QTL mapping of wheat in 2005 as a Junior Research Fellow.

      I have little information regarding the QTL training and analysis which might be useful for new students starting career in Quantitative Genetics.

      I went to attend Summer Institute in Statistical Genetics at NC State University in 2005 and find it really useful. QTL Mapping module designed by R. Doerge and Z. Zeng was fantastic and personally recommend it for all new students working in QTL data analysis. Other courses on Advanced QTL Mapping, Quantitative Genetics, Statistics in Functional Genomics and Proteomics, Pedigree Data Analysis and Computing for Statistical (by T. Lumley and K. Rice) are also highly popular.

      I was funded from NIH/NSF via course grant and the travel fellowship was provided by Society of Systems Biologists.

      This year they just finished on June 29, 2007 at University of Washington. The same course will be running in Europe called as European Institute in Statistical Genetics September 3 – September 12, 2007 at University of Liège, Belgium.

      If anyone is interested then Full course details are here.

      Thanks,
      Amit

    • Hi,
      thanks for the information on the Summer Institute in Statistical Genetics (SISG) at the University of Washington, Seattle, and its European counterpart in Belgium! This course is indeed very good – I also had the chance to attend it (last year), and took the modules on Probability and Statistical Inference, Regression Analysis, MCMC in genetics and advanced MCMC in pedigree analysis. Unfortunately, I wasn’t able to attend the QTL module which would probably have been very useful for what I am doing now…so I am thinking of doing it in Belgium in September.

      I can also recommend the Wellcome Trust Advanced Courses, I did the one on complex diseases, and it was also excellent.

      One of the reasons why I set up this group is because I felt I learned so many useful things at those courses last year, but it is so easy to just fall back into the normal daily routine after the course has ended…maybe through being able to discuss things here, we’ll be able to keep these things freshly in minds?

    • Hi, my interest is more on QTL mapping and identifying the candidate genes in the QTL regions for resistance to fungal pathogens of rice. From previously published QTL maps, we have identified putative candidate genes and used this as markers for association studies in rice.

    • Hi,

      I have just finished a 5 year postdoc at NIEHS. I stayed on as a Research Fellow. I am interested in cardiovascular genetics. My main projects concern the genetics of heart rate and heart rate variability. I am using an inbred strain screen, a large F2 cohort and an RI strain set for QTL mapping by traditional positional cloning, in silico mapping and WebQTL (genenetwork.org). These projects are at varying stages of completion.

      I also have other projects using knockout and transgenic mouse models. I spend a lot of time recording and analyzing mouse ECG!

    • Hi,
      Actually the next year I’m going to work with some blood samples of patients with BP1. I’m not an expert in this area, but I’m sure we can share some interesting comments… hehe
      take care
      I study in Bogota at the Pontificia Universidad Javeriana.
      :)
      take care

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