For more information on this topic, please refer to the State of the Art and Discovery articles in the January 2008 issue of Clinical Pharmacology & Therapeutics.

1. Techniques such as imaging, pathology, surgery, radiation oncology, and medical oncology have decreased breast cancer mortality rates.
What other preventative methods, treatment techniques, and alternative therapies exist that have not been fully explored?

2. Have previous studies using tamoxifen to prevent invasive breast cancer in high-risk patients effectively measured its effect on overall survival?

3. Should neoadjuvant endocrine therapy for patients with locally advanced breast cancer be reserved for clinical trial use?

4. Will a “personalized medicine” approach integrating gene profiles and other predictive tools shape future therapies for breast cancer?