Could this be a possible treatment for HIV/AIDS:

Synthesize a peptide nucleic acid antisense oligonucleotide for HIV’s env gene’s mRNA. The reason for using PNA is that it is substantially more resistant to enzyme degradation by nucleases and proteases. The reason for choosing the gag gene is that it’s proteins, p24, p17, p7, and p6, code for the basic physical infrastructure of HIV; w/o these key proteins, there is no HIV. Then, encapsulate the oligonucleotides in liposomes studded w/ anti-CD4 antibodies. This will ensure 1) toxicity is limited—cf Ambisome, the liposomal preperation of amphotericin B—2) the biologic goes only where it’s needed, which is the cytoplasm of CD4+ T-cells. Decorating the liposome w/ anti-CD4 antibodies will trigger endocytosis, in my limited knowledge, at least. I predict low toxicity and high efficacy in reducing the patient’s viral load to 0 copies/ml.

What are your thoughts? Should LNA instead of PNA be used? Cell-penetrating peptides vs. liposomes? Targeting the gag gene vs. targeting the pol gene? Are there any publications about this subject?

And, just for fun, what do you think the generic name would be for this biologic? Brand name?

Thanks!!!!