How do I know if breast cancer information is reliable? (1 reply)

kennis john — Mon, 18 Aug 2008 22:38:30 -0000

How do I know if breast cancer information is reliable?

Cancer stem cells and breast cancer molecular subtypes (0 replies)

Jason Herschkowitz — Thu, 03 Apr 2008 04:44:31 -0000

A key paper published in 2003 by Al-Hajj et al. link prospectively identified and isolated tumor initiating cells (also called cancer stem cells) as CD44+CD24-/low Lin-neg from a series of plural effusions. Many studies have since used these markers. An unanswered question remains whether these markers identify tumor initiating cells, and whether a rare tumor initiating cell population exists, in all subtypes of breast cancer. It has always been my thought that different subtypes of breast cancer would have tumor initiating cells identified by different markers.

A recent paper was published in PNAS(Horwitz et al. 2008 link) showing a rare CD44+ ER- PR- K5+ tumor initiating cell present in xenografts of T47D, a luminal subtype cancer cell line. Therefore, maybe some human luminal tumors (perhaps luminal B)contain rare steroid negative tumorigenic cells which would be expected to be refractory to endocrine therapy and could survive and repopulate the tumor.

Basal-like vs Triple Negative: are they the same? (0 replies)

Jason Herschkowitz — Thu, 27 Mar 2008 03:20:47 -0000

There have been recent questions about whether basal-like (defined by microarray) and triple negative (defined by IHC as ER, PR, and HER negative) are one and the same thing. Comments?

Nature Network - Recent topics from Breast cancer molecular subtypes

How do I know if breast cancer information is reliable? (1 reply)

Cancer stem cells and breast cancer molecular subtypes (0 replies)

Basal-like vs Triple Negative: are they the same? (0 replies)