Nature Network - Recent topics from Genetics The most recent forum topics from Genetics http://network.nature.com/forum/GDEC501B5 en-us 40 Hello! (2 replies) Hello everyone….
I’m new here..and am in search of information regarding the future after post garaduation in Msc. Genetics!!
If any of you could help me!!

]]> Tue, 26 Feb 2008 19:12:33 -0000 http://network.nature.com/forums/GDEC501B5/1118 Alisha S http://network.nature.com/forums/GDEC501B5/1118 New Molecular genetics group! (0 replies) Hey everyone! I am new to this group, and was wondering if anyone is interested in joining another similar group which I have just set up called: Molecular Genetics & The RNA World! Hope you find the forum topics interesting, and feel free to add your own!

]]> Tue, 05 Feb 2008 19:05:50 -0000 http://network.nature.com/forums/GDEC501B5/1005 Adam Hall http://network.nature.com/forums/GDEC501B5/1005 Transplanted primordial germ cells produced viable gametes (and offspring!) (0 replies) Primordial germ cells (PGC) were transplanted across species, even across genera, into zebrafish with host PGC inactivated by Dead End Morpholinos. Offspring were produced after natural spawning from gametes made by daughter cells of the transplanted PGC.

Saito T, Goto-Kazeto R, Arai K, Yamaha E.
Xenogenesis in Teleost Fish Through Generation of Germ-Line Chimeras by Single Primordial Germ Cell Transplantation.
Biol Reprod. 2007 Sep 26; [Epub ahead of print]

]]> Tue, 02 Oct 2007 00:06:03 -0000 http://network.nature.com/forums/GDEC501B5/574 Jon Moulton http://network.nature.com/forums/GDEC501B5/574 Break the silence (0 replies) This has been a quiet forum, so I will try to break the ice.

A technique for associating a function with a gene is to knock down the expression of the gene and observe the resulting changes in cells or organisms. I work with Morpholino antisense oligos, molecules that can be targeted to halt translation, redirect splicing or block miRNA maturation. These oligos are usually used in embryonic studies of zebrafish, Xenopus, Ciona or other developmental model organisms, but they are also applicable in cell cultures. Their use in intact adult organisms is limited by cytosolic delivery, with is too slow to be experimentally useful in most cells. New techniques, such as covalently attaching cell penetrating peptides to Morpholinos, have shown promise as adult in vivo delivery techniques.

What are the rest of you working on?

Regards,

- Jon

]]> Fri, 03 Aug 2007 18:43:23 -0000 http://network.nature.com/forums/GDEC501B5/368 Jon Moulton http://network.nature.com/forums/GDEC501B5/368