Hi,
I am an undergraduate student and I am taking a class on X-ray Techniques in Chemistry. Mostly we are looking at inorganic crystallography. However, for our project presentation I am looking at the new GPCR structure.
My question is as follows:
In inorganic crystallography, we have a single crystal where we are able to align the molecules in a uniform plane to enable diffraction.
But, biomolecules are complex, how do you achieve alignment.
I have read about using metal ions/ligands to enable alignment, but that changes the native conformation of the protein.
I hope my question is not too broad. Could you direct me to some research articles, so that I have better understanding of the technique difference between inorganic and biomolecule crystallography.
Thank you very much for your time and advice.

Shirin.