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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:iCalendar-Ruby
BEGIN:VEVENT
LAST-MODIFIED:20080325T165138
SEQUENCE:0
CONTACT:katie.sedat@abcam.com
ORGANIZER:Dr. Brendan Price and Dr. Ralph Scully in association with Abcam\
 , Inc.
DTEND:20080529T170000
UID:2008-05-16T02:41:07-0400_461092072@socialweb1
DESCRIPTION:The 2008 "Cellular Responses to DNA Damage" Symposium will expl
 ore the links between chromatin dynamics\, histone modification and the rep
 air of DNA double strand breaks. The compact nature of chromatin presents a
  significant barrier to DNA-dependent transactions\, including gene transcr
 iption and DNA replication. Access to specific regions of chromatin is regu
 lated at multiple levels\, including remodeling of chromatin structure\, lo
 cal deposition of specific histone variants\, post-translational modificati
 on of histones and the recruitment of specific proteins to these modified h
 istones. The ability of cells to detect and repair DNA double strand breaks
  appears to be dependent on many of these same regulatory processes. By bri
 nging together a diverse array of experts from the fields of chromatin stru
 cture\, histone modification\, chromatin remodeling and DNA double-strand b
 reak repair\, this symposium aims to highlight the critical role of histone
 s and chromatin structure in the detection and repair of DNA double strand 
 breaks.
\n
\nTopics to be discussed include:
\n
\n* Higher order chromatin 
 structures and double strand break repair.
\n* Chromatin remodeling complex
 es implicated in the repair of DNA breaks.
\n* Chromatin structure adjacent
  to DNA double strand breaks.
\n* The role of histones and histone modifica
 tions in DNA damage signaling\, including key modifications such as H2AX ph
 osphorylation\, histone methylation and histone ubiquitination.
\n
\n* Form
 ation of DNA repair complexes at DNA double strand breaks. 
SUMMARY:Cellular Responses to DNA Damage 2008
DTSTART:20080529T090000
CREATED:20080211T163637
DTSTAMP:20080516T024107
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