Welcome and Opening Remarks Chairperson: Irwin M. Arias, Tufts University School of Medicine 9:00 a.m. Extracellular ATP : Secretion, Hydrolysis and Signaling Guido Guidotti, Harvard University 9:40 a.m. Lipid Rafts in Membrane Trafficking and Cell Polarization Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics 10:20 a.m. Morning Break 10:50 a.m. How Studies of Flagellar Development in a Green Alga Lead to the Pathobiology of Cilia Joel Rosenbaum, Yale University 11:30 a.m. Cholangiocytes, Cilia and Cysts: What’s the Connection? Nicholas F. LaRusso,Mayo Clinic College of Medicine 12:00 p.m. Luncheon with Faculty 1:00 p.m. Hepatic Tissue Engineering at the Microscale Sangeeta Bhatia, Massachusetts Institute of Technology 1:40 p.m. The Intersection of Manifest Destiny and Mitochondria – Navajo Neurohepatopathy Steve Holve, Tuba City Indian Medical Center 2:10 p.m. Modeling Human Liver Development, Physiology and Disease in Zebrafish Michael A. Pack,University of Pennsylvania 2:40 p.m. Afternoon Break 3:00 p.m. Autophagy in Aging Liver: Getting the Cleaning Crew Back to Work Ana Maria Cuervo, Albert Einstein College of Medicine 3:30 p.m. Extending Lifespan by Nutrient Control of Liver Metabolism: Effects of Caloric Deprivation and Red Wine Pere Puigserver, Harvard Medical School 4:00 p.m. Concluding Comments: Irwin M. Arias, MD 4:05 p.m. Wine and Cheese Reception

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