• Cancerevo: Evolution and cancer

    Studying cancer as an evolutionary disease. News and reviews about research on cancer and evolution from a theoretician perspective.

    • Mercenary immune cells can fight your cancer

      Friday, 21 Sep 2007 - 18:22 GMT

      Work in Lyon went quite well and asides from making sense of some data we welcomed a physician on board our project. Also I got to learn more about a project in which my collaborator in Lyon, Benjamin Ribba, is involved. I got to know about ETOILE (French for star), the project in which haedrontherapy will be used to treat some specific patients. This type of therapy works in a similar way to radiotherapy but can be controlled so it affects only the part of the tissue affected by the tumour. For reasons that I still ignore it is mainly used in very young or older patients and requires fairly sophisticated (as in expensive and big) installations.

      Also this week I found this piece of news reported at the BBC’s website about research by scientists at Wake Forest show how white blood cells (granulocytes) from one person can help treat a cancer in a different one. Interestingly the article mentions that granulocytes (which according to wikipedia that refers in many cases to neutrophils) are not normally thought to be relevant in cancer research. That should support the research of people (Antonio Bru at UCM comes to mind here) studying how the non adaptive part of the immune system (neutrophils) could be leveraged as a cancer therapy.

      A second interesting finding is that the granulocyte count in patients with cancer is lower than in healthy people and that even in that case this number changes in the year with higer counts in the spring/summer and lower in the autumn/winter. Could it be that (and I not claiming it is my idea, I heard it before) a tumour is more likely to start when the immune system is depressed?

      It is also interesting that this researchers found how (at least in mice) to transplant cancer-fighting granulocytes from one individual to another. Since different people have different immune systems that could imply that we could use our own diversity as a species to fight tumours, whose growth could be explained as cells taking advantage of somatic evolution

      Last updated: Friday, 21 Sep 2007 - 18:22 GMT


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